Lung cancer

Lung cancer remains a particularly challenging issue locally and prognosis is very poor, with a five year survival rate of less than 10%. The main reason for this is that patients tend to present with advanced disease at a point when curative surgery is no longer feasible.

Locally, there is a need to focus on early diagnosis, with the aim of reducing the number of patients presenting to secondary care in advanced stages of lung cancer.

TOHETI aims to understand and evaluate the uptake of low-dose chest CT by high risk symptom-free individuals (patients aged 55-80, who are current or former smokers (last 15 years)), when offered as part of a lung health clinic assessment.

To maximise access to and uptake across the study, Guy’s and St Thomas’ has been exploring different ways to engage those who may benefit from participating in our study across our local community, including GPs, pharmacists and smoking cessation services.

TOHETI’s work feeds into the nationwide ACE programme (Proactive approach to patients at High Risk of Lung Cancer):

Proposed benefits:

  • To increase early detection and improve prognosis.
  • To explore the possibility of direct access for GPs of asymptomatic patients to low dose CT.
  • To increase understanding of non-compliance, and potential barriers in attitude to uptake of low-dose CT screening for future.

Engagement & co-operation from our General Practitioner colleagues in expressing an interest in participating with the study has been overwhelmingly positive – with responses such as ‘We will be happy to take part esp. if your study can pick up lung cancer early - benefit for our patients’’ Dr Jayanthan Manoharan, GP Partner & GP Tutor/OOH , Supervisor Streatham Hill Group Practice.

Study snapshot:

The lung health study which aims to evaluate the uptake of low-dose chest Computed Tomography (CT) when offered as part of a lung health clinic assessment, in patients aged 55-80 who are current or former smokers (quit within the last < 15 years) identified in two boroughs of South East London is now in its 13th month of recruiting patients.

So far 17 GP practices in Lambeth and Southwark have sent over 14,000 invitation packs to patients who are identified as high risk (within the Lambeth & Southwark area).

Over 360 participants have been enrolled on between July 2017 and August 2018 with 19 participants referred for further investigations ( either to a cancer clinic or chest clinic) in accordance with study protocol. We have had 4 confirmed cancer diagnosis. All under 1B staging category.

Study will inform on the value of a simple initial screen in a high-risk population, the effect of smoking cessation in this high-risk group and cost-effectiveness of this screening.

**For more information on if you may be eligible to participate, contact lung-toheti@kcl.ac.uk or call 0207 8489 530

Download a copy of the Patient Information Leaflet here.

Download a copy of our participation questionnaire here. This will help us determine if you are eligible to take part in the study.


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X ray chest